Active — Not RecruitingNot Applicable

Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity

United Kingdom20 participantsStarted 2024-02-05

Plain-language summary

The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40. The main questions it aims to answer are: Does FUS applied to the cerebellum affect cognition? Does FUS applied to the white matter or gray matter of the cerebellum with the same parameters result in different outcomes? Researchers will compare active and sham stimulations. Participants will be asked to complete cognitive tasks after receiving FUS to the cerebellum.

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion Criteria: * Participants must not have claustrophobia or anxiety regarding MRI scan. * Participants must not have current or planned pregnancy. * Participants must not have history of neurological or psychiatric disorder. * Participants must not have predisposition for fainting spells (syncope). * Participants must not have implanted material (e.g., pacemaker, neurostimulator, medication infusion device, cochlear implants). * Participants must not have medical patch that cannot or may not be taken off (e.g., nicotine patch). * Participants must not be currently taking psychoactive medication, or must have stopped taking such medication for at least 2 weeks before starting experiment (excluding contraception). * Participants must not have skin disease on or close to the scalp. * Participants must not have direct relatives (parents, siblings, children) with epilepsy, convulsion, or seizure. * Participants must abstain from the use of any recreational drugs in the 48-hour period prior to taking part in the experiment. * Participants must not consume more than 4 alcoholic units within the 24-hour period before participation.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Electroencephalogram (EEG) power and spatiotemporal dynamics

Timeframe: Through study completion, peri-procedurally, on days 1, 2 and 3

Electrooculogram (EOG) power and spatiotemporal dynamics

Timeframe: Through study completion, peri-procedurally, on days 1, 2 and 3

Trial details

NCT IDNCT07389447

SponsorUniversity of Nottingham

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-31

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