Prospective Longitudinal Monocentric Study to Measure Limb Movement in Patients With FGFR3-relate… (NCT07388966) | Clinical Trial Compass
RecruitingNot Applicable
Prospective Longitudinal Monocentric Study to Measure Limb Movement in Patients With FGFR3-related Skeletal Dysplasia
France40 participantsStarted 2026-02-06
Plain-language summary
The study aims to identify which Syde®-derived digital outcomes are reliable in FGFR3-related Skeletal Dysplasia. This requires to set-up a natural history study to measure limb movements in patients with ACH or HCH.
Who can participate
Age range3 Years – 65 Years
SexALL
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Inclusion criteria
✓. Aged 3 years old or older at the time of consent.
✓. Written informed consent obtained:
✓. From the parent(s) or legal guardian(s) for participants under 18 years old.
✓. From participants 18 years old and older.
✓. Affiliated to, or beneficiary of a social security category
✓. Able to walk unassisted for at least 10 meters.
✓. Genetically confirmed diagnosis with one pathogenic variant (ACMG class IV \& V) of achondroplasia or hypochondroplasia.
✓. Participant (and caregivers for participants under 18 years old) willing and able to comply with all study procedures including: questionnaires, Syde® related procedures
Exclusion criteria
✕. Subjects who have short stature condition other than ACH/HCH.
✕. Presence of cognitive disorders that limit their understanding of the data collection process (training of device use and 4-week recording periods every 6 months, device return at the end of the study), the implication of the study and consent.
✕. Presence or history of any concurrent disease or condition that could interfere with study participation, impact pediatric growth, affect motor or balance or gait function (such as neurological, endocrine, infectious, allergic, osteoarthritis, or inflammatory), assessed by the investigator.
What they're measuring
1
Reliability of digital endpoint derived from Syde® assessed by the Intra-Class Correlation (ICC) for each recording period timepoint.