Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery (NCT07387822) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery
China352 participantsStarted 2026-02-10
Plain-language summary
This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative "Individualized Open Lung Ventilation" strategy compared to a standard lung-protective ventilation strategy in patients undergoing thoracic surgery.
One-lung ventilation (OLV) is essential for thoracic surgery but can cause lung injury. While standard care often uses fixed ventilation parameters, this study investigates whether personalizing Positive End-Expiratory Pressure (PEEP) to achieve the lowest driving pressure can reduce the incidence of postoperative pulmonary complications (PPCs) within 7 days after surgery.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 to 75 years.
* American Society of Anesthesiologists (ASA) physical status I-III.
* Body mass index between 18 and 30 kg/m².
* Scheduled for elective video-assisted thoracoscopic surgery (VATS).
* Expected duration of one-lung ventilation longer than 1 hour.
* Able to understand the study procedures and provide written informed consent.
Exclusion Criteria:
* Pregnancy or breastfeeding.
* Emergency surgery or reoperation.
* History of severe pulmonary disease, including chronic obstructive pulmonary disease, pulmonary fibrosis, severe emphysema, pulmonary bullae, pneumothorax, or uncontrolled asthma.
* History of heart failure or coronary artery disease.
* Previous thoracic surgery or mechanical ventilation within 1 month before surgery.
* Planned postoperative mechanical ventilation.
* Bilateral thoracic surgery.
* Participation in another interventional clinical trial.
* Conversion to open thoracotomy during surgery.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of postoperative pulmonary complications within 7 days