By InvitationNot Applicable

Screening in Relatives With Elevated Risk for Unruptured Intracranial Aneurysms

Serbia300 participantsStarted 2026-02-01

Plain-language summary

The purpose of this study is to screen first-degree relatives of patients with aneurysmal subarachnoid hemorrhage using magnetic resonance angiography to detect unruptured intracranial aneurysms. This study aims to identify individuals who are at increased risk and determine the effect of environmental factors for development of unruptured intracranial aneurysms.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. First-degree relatives (parents, siblings, or children) of patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH);
✓. Age ≥ 30 years at the time of enrollment, and current cigarette smokers or diagnosed with hypertension (either treated or untreated);
✓. Able and willing to undergo magnetic resonance angiography (MRA);

Exclusion criteria

✕. History of intracranial aneurysm rupture or prior subarachnoid hemorrhage;
✕. Contraindications to MRI/MRA (e.g., pacemaker, metallic implants, severe claustrophobia) or pregnancy (due to MRI safety considerations);
✕. A history of polycystic kidney disease, Marfan's Syndrome, Ehlers Danlos Syndrome, or fibromuscular dysplasia;
✕. Unable or unwilling to provide informed consent;
✕. Participation in another interventional study that could interfere with outcomes.

What they're measuring

Detection of unruptured intracranial aneurysms by magnetic resonance angiography (MRA).

Timeframe: At the time of screening (single MRA examination)

Trial details

NCT IDNCT07387575

SponsorUniversity of Novi Sad

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-01-31

View on ClinicalTrials.gov More Intracranial Aneurysms trials