Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes (NCT07386327) | Clinical Trial Compass
RecruitingNot Applicable
Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes
Turkey (Türkiye)90 participantsStarted 2026-03-09
Plain-language summary
D5W) has long been used as an intravenous fluid for hydration and energy supplementation and has recently gained increasing clinical interest in perineural injection therapies and ultrasound-guided hydrodissection. D5W has been shown to improve pain and functional outcomes in entrapment neuropathies by mechanically releasing perineural adhesions and potentially modulating neurogenic inflammation. In contrast, 0.9% sodium chloride (normal saline) is routinely used as a dilution medium for local anesthetics in peripheral nerve blocks; however, emerging evidence suggests that alternative diluents such as D5W may influence block onset and efficacy.
The infraclavicular block is a commonly used ultrasound-guided technique for brachial plexus anesthesia, providing reliable anesthesia and postoperative analgesia for upper extremity surgery. This study aims to compare the effects of diluting bupivacaine with either D5W or 0.9% NaCl on block success and duration of analgesia in patients undergoing infraclavicular block. Secondary outcomes include block onset characteristics, sensory and motor block profiles, and perioperative analgesic requirements. The findings may help determine whether D5W represents a safe and effective alternative diluent to saline in routine regional anesthesia practice.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients who agree to participate in the study and provide written informed consent
* Patients scheduled for elective upper extremity surgery for whom infraclavicular block is considered appropriate for anesthetic management
* Age between 18 and 65 years
* American Society of Anesthesiologists (ASA) physical status I-III
* Patients with a normal neurological examination in the extremity scheduled for peripheral nerve block
Exclusion Criteria:
* Patients who decline to participate in the study or refuse to provide informed consent
* History of allergy or hypersensitivity to study medications
* Body mass index (BMI) ≥ 30 kg/m²
* Body weight less than 40 kg
* Age below 18 years or above 65 years
* History of significant cardiac disease (e.g., arrhythmia, conduction disorders)
* Presence of coagulopathy (international normalized ratio \[INR\] \> 1.5 and/or platelet count \< 100,000/mm³)
* Hepatic failure or significant liver dysfunction
* Pregnant patients
* Infection at the planned peripheral block site
* Presence of neurological deficit in the extremity planned for peripheral nerve block
* Patients with uncontrolled diabetes mellitus and/or established diabetic neuropathy
* American Society of Anesthesiologists (ASA) physical status IV
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Sensory block onset time
Timeframe: Assessed at 5, 10, 15, 20, and 30 minutes after block administration.