Collagenic vs Collagen-enriched Graft in Sinus Elevation: RCT

Inclusion Criteria: * Patient requiring vertical elevation of the maxillary sinus floor. * Residual alveolar bone height of edentulous maxilla below the floor of the maxillary sinus \<5 mm. * Males and females between 30-80 years old * Patients with healthy periodontal conditions (treated periodontitis, PI\<25%, BoP\<25%). * Patients willing to sign an informed consent and participate in a clinical study. * Generally fit and healthy and able to undergo oral surgical procedures under local anesthesia. * Teeth at the surgical site requiring extraction were removed at least 12 weeks prior to sinus floor elevation. Exclusion Criteria: * Patients who smoke more than 5 cigarettes/day * Pregnancy (confirmed by verbal inquiry) * Chronic systemic pathologies (e.g. diabetes) and neoplasms of the oro-facial district. * Patients undergoing treatment with antiresorptive agents. * Patients receiving systemic corticosteroid therapy. * Any site with a history of implant failure. * Dental sites with acute infections. * Chronic inflammatory diseases of the oral cavity. * Autoimmune diseases. * Documented hypersensitivity to any of the medications intended for use during the treatment protocol. * Substance abusers. * Patients with known collagen hypersensitivity. * Patients with hypersensitivity to porcine-derived materials. * History of malignant tumors of the maxillary sinus. * History of head/neck radiation therapy.