Effect of JointIQ on Joint Discomfort in Healthy Subjects

Inclusion Criteria: * Healthy male or female adults, aged 18 to 75 years, with a body mass index (BMI) of 18-30 kg/m². * Actively participates in regular exercise, including but not limited to soccer, basketball, tennis, rugby, running, or cycling, and engages in at least two training sessions per week during the study period. * Experiences pain ≥5 on a Visual Analog Scale (VAS) during the Single-Leg Step-Down (SLSD) test when performing 30 to 150 steps. * Has experienced knee discomfort within the last 3 months during or after physical activity. Exclusion Criteria: * Participation in another clinical trial within 30 days prior to study enrollment. * Uncontrolled diabetes or currently using insulin therapy. * Current smokers. * History of heart failure. * Previous bilateral knee replacement surgery. * Current use of prescription COX-2 inhibitors, chondroitin sulfate, glucosamine sulfate or hydrochloride, collagen, fish oil, or vitamin D supplements and unwilling to discontinue these during the study. * Likely to be lost to follow-up, non-compliant, or requiring concomitant medication that may interfere with study outcomes. * Received intra-articular treatment within 3 months prior to study start. * Medical conditions that may interfere with study results, such as cancer, cardiovascular disease (e.g., stroke, myocardial infarction), pregnancy, or breastfeeding. * Hip, spine, or foot injuries that could affect study outcomes.