Not Yet RecruitingNot Applicable

Role of Subgingival Instrumentation in Oral Lichen Planus

India30 participantsStarted 2026-03-01

Plain-language summary

The goal of this interventional study is to assess the clinical and histopathological changes in Oral Lichen Planus patients with gingival involvement pre and post subgingival instrumentation. Objective- Primary objective: To observe and evaluate the clinical signs and symptoms in Oral Lichen Planus with gingival involvement. Secondary objective: To observe and evaluate the Cluster of Differentiation (CD) 4+ and 8+T lymphocytes in Oral Lichen Planus with gingival involvement. Study group: 30 cases of Oral Lichen Planus with gingival involvement

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * Clinically and histopathologically confirmed cases of OLP. * OLP predominantly involving the gingiva. * Consent obtained. Exclusion criteria: * Cases which does not fulfil either clinical or histopathological criteria. * Unwilling to participate in the study. * Patients with recorded history of factors that might modify immune response (such as patient on corticosteroids or medically compromised patients or suffering from heart diseases). * Cases undergoing treatment of OLP within past 6 months. * Biopsies with inadequate or non-representative samples * Cases histopathologically diagnosed as Lichenoid Dysplasia or Oral Lichenoid Lesions. * Cases diagnosed with autoimmune disorders.

What they're measuring

Change in clinical signs and symptoms in cases of oral lichen planus

Timeframe: At baseline and after end of treatment at 4 weeks

Trial details

NCT IDNCT07381595

SponsorPostgraduate Institute of Dental Sciences Rohtak

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

Contact for this trial

Mala Kamboj, MDS

+919466902477 malskam@gmail.com