CompletedNot Applicable

Dynamic Magnesium Replacement Strategies and 28-Day Mortality in Non-Cardiac Critically Ill Patients With Hypomagnesemia: A Target Trial Emulation

China12,887 participantsStarted 2025-09-01

Plain-language summary

This study looks at how different ways of giving magnesium (a nutrient) affect the risk of death within 28 days for adults with low magnesium levels who are in the intensive care unit (ICU) for non-heart-related reasons. We will use data from past ICU patients (2008-2019) to compare three approaches: No magnesium treatment (even if levels are low); Daily magnesium treatment (regardless of daily levels); Dynamic treatment (only giving magnesium when daily tests show low levels). The goal is to find out which strategy is safest and most effective for this group of patients.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age ≥ 18 years.
✓. Admitted to the Intensive Care Unit (ICU).
✓. Developed hypomagnesemia (Serum Magnesium \< 1.7 mg/dL) within the first 72 hours of ICU admission.

Exclusion criteria

✕. Admitted due to cardiac or cardiosurgical causes (e.g., Cardiac Surgery Recovery Unit, CCU, CVICU).
✕. Underwent cardiac surgery during hospitalization (identified by ICD-9/10 procedure codes).
✕. Primary discharge diagnosis of major cardiac conditions (e.g., myocardial infarction, heart failure, arrhythmias).

What they're measuring

28-Day All-Cause Mortality

Timeframe: 28 days after t0

Trial details

NCT IDNCT07380542

SponsorFujian Provincial Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-31

View on ClinicalTrials.gov More Hypomagnesemia trials