By InvitationNot Applicable

Comparative Analysis of Salivary and Bronchoalveolar Lavage IL-6 and TNF-α as Biomarkers in Pediatric Acute Respiratory Distress Syndrome

Egypt37 participantsStarted 2025-05-01

Plain-language summary

The aim of this study is to determine the degree of agreement in cytokines level measured through BAL and those measured through salivary glands excretion. and to compare the validity of cytokines in BAL versus salivary secretion in predicting the stage of ARDS and disease outcome in term of mortality, disease progression and length of stay.

Who can participate

Age range1 Year – 10 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Clinical diagnosis of Pediatric Acute Respiratory Distress Syndrome (ARDS) * Age range: 1 month to 18 years * Requirement for invasive mechanical ventilation * Availability of salivary and bronchoalveolar lavage (BAL) samples within 24 hours of ARDS diagnosis * Informed consent obtained from parent or legal guardian Exclusion Criteria: * Pre-existing chronic lung disease (e.g., cystic fibrosis, bronchopulmonary dysplasia) * Known immunodeficiency or current immunosuppressive therapy * Active malignancy or receipt of chemotherapy within the past 6 months * Severe congenital anomalies incompatible with survival * Refusal or inability to obtain informed consent

What they're measuring

Agreement between BAL and salivary cytokine levels

Timeframe: Within 24 hours of ARDS diagnosis

Trial details

NCT IDNCT07380373

SponsorAin Shams University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-04-01

View on ClinicalTrials.gov More ARDS (Acute Respiratory Distress Syndrome) trials