Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress (NCT07375238) | Clinical Trial Compass
RecruitingNot Applicable
Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress
Spain80 participantsStarted 2026-03-02
Plain-language summary
The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality. The study will also examine how this dietary intervention affects oxidative stress and whether it is well tolerated.
The main questions this study aims to answer are:
* Does daily consumption of gazpacho improve semen quality in men with altered semen parameters?
* Does this dietary intervention affect levels of oxidative stress in semen?
* Is daily gazpacho intake feasible and well tolerated as part of a Mediterranean diet?
Researchers will compare a Mediterranean diet plus daily gazpacho intake with a Mediterranean diet alone to determine whether adding gazpacho provides additional benefits for male reproductive health.
Participants will:
* Follow a standardized Mediterranean diet for 12 weeks
* Drink 330 mL of gazpacho every day or follow the diet without gazpacho
* Provide semen samples at the start of the study and after 12 weeks
* Complete a short diary to record adherence to the dietary intervention
* Be followed for up to 18 months to record reproductive outcomes
Who can participate
Age range
18 Years – 45 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men aged 18 to 45 years
* Andrological profile including altered semen parameters such as oligozoospermia, asthenozoospermia and/or teratozoospermia (O±A±T)
* No clinical indication for sperm DNA fragmentation testing or advanced sperm selection techniques
* Willingness and ability to comply with the study protocol, including adherence to a standardized Mediterranean diet
* Signed and dated written informed consent form
Exclusion Criteria:
* Use of antioxidant supplements during the three months prior to study start.
* Active smokers or men who have stopped smoking within the last three months.
* Diagnosis of azoospermia, leucocytospermia or necrozoospermia.
* Presence of severe systemic diseases or chronic conditions that could interfere with semen quality or adherence to the study.
* Known allergy or intolerance to any ingredient of the gazpacho used in the study.
* Any medical, psychological or social condition that, in the investigator's judgement, could compromise the subject's ability to participate fully or comply with the protocol requirements.
* Simultaneous participation in another clinical study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.