Active — Not RecruitingNot Applicable

Clinical and Radiographic Evaluation of Local Melatonin Application on Osseointegration of Immediate Mandibular Implants

Egypt16 participantsStarted 2025-09-01

Plain-language summary

Clinical and Radiographic Evaluation of Local Application of Melatonin on Osseointegration of Immediate Dental Implants for Mandibular Single Rooted Teeth: A Randomized Controlled Study

Who can participate

Age range21 Years – 60 Years

SexALL

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Inclusion criteria

✓. Patients aged between 21 and 60 years.
✓. Good general health (ASA I).
✓. Non-smokers or light smokers (\<10 cigarettes/day).
✓. Presence of a single non-restorable mandibular tooth indicated for extraction (incisor, canine, or premolar).
✓. Adequate bone volume to receive a dental implant.
✓. Patients with good oral hygiene.

Exclusion criteria

✕. Medically compromised patients (e.g., uncontrolled diabetes, immunosuppressive therapy, bisphosphonate use)
✕. Pregnant and lactating women.
✕. Active periodontal disease at the implant site.
✕. Acute infection at the extraction site (abscess or sinus tract).
✕. Severe parafunctional habits (e.g., bruxism, clenching).

What they're measuring

Implant stability (ISQ)

Timeframe: Immediately postoperatively and at 6months postoperatively

Trial details

NCT IDNCT07374523

SponsorSuez Canal University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-01

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