Not Yet RecruitingNot Applicable

Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression

142 participantsStarted 2026-01-18

Plain-language summary

A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients with Mild-to-Severe Depression

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age ≥ 18 years.
✓. Scheduled to undergo elective breast cancer resection surgery.
✓. American Society of Anesthesiologists (ASA) physical status classification of I-III.
✓. Clearly understand and voluntarily agree to participate in the study, and sign the informed consent form.
✓. Female patients with mild to severe depressive symptoms (defined as a Hospital Anxiety and Depression Scale-Depression subscale score of ≥8)
✓. Anticipated anesthesia duration greater than 90 minutes.

Exclusion criteria

✕. Patients with significant preoperative abnormalities in cardiac, pulmonary, hepatic, or renal function, or coagulation disorders .
✕. Patients taking antipsychotics, antidepressants, or glucocorticoids, or with a history of alcohol abuse or illicit drug use .
✕. Patients with an MMSE score \<18, dementia, intellectual disability, or those unable to communicate (e.g., coma, severe dementia, hearing or language impairment) .
✕. Patients with a history of psychiatric or neurological disorders (e.g., schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis) .
✕. Patients with poorly controlled or untreated hypertension (≥180/110 mmHg) .
✕. Patients with elevated intracranial or intraocular pressure.
✕. Patients with untreated or inadequately treated hyperthyroidism .
✕. Patients with a known allergy to the drugs involved in this study .

What they're measuring

Perioperative anxiety and depreession

Timeframe: Preoperative day 1, postoperative day 3, day 7 and day 30

Trial details

NCT IDNCT07374198

SponsorChinese PLA General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-18

Contact for this trial

WEIDONG MI

133810829 wwdd1962@163.com

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