CompletedNot Applicable

Evaluation of the Efficacy of Injectable Platelet-Rich Fibrin Mixed With Hyaluronic Acid in Treatment of Temporomandibular Joint Internal Derangement

Egypt30 participantsStarted 2023-08-10

Plain-language summary

we inject I-PRF and Hyaluronic Acid inside the human TMJ with internal derangement after arthrocentesis, and follow-up is made to evaluate the effect of this treatment.

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. patients aged from 18 to 40 years old.
. patients diagnosed with internal derangement of TMJ, suffering from limited mandibular movements, joint pain and clicking.
. Patients who are free from any systemic disease (ASA I).

Exclusion criteria

. Patients who have myofascial pain dysfunction syndrome only.
. Patients who have previous surgery in TMJ.
. Patients who have previous arthrocentesis within 1 year.
. Patients with prosthetic joint replacement.
. Patients allergic to any components of the injecting solution.
. Patients who received previous trauma to the joint.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Maximum mouth opening

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Lateral to Right movement

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Lateral to Left movement

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Protrusive movement

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Joint Clicking

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Joint Pain

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Trial details

NCT IDNCT07373730

SponsorSuez Canal University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-20

View on ClinicalTrials.gov More Temporomandibular Joint Disc Displacement trials

Who can participate

Age range

18 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. patients aged from 18 to 40 years old.
. patients diagnosed with internal derangement of TMJ, suffering from limited mandibular movements, joint pain and clicking.
. Patients who are free from any systemic disease (ASA I).

Exclusion criteria

. Patients who have myofascial pain dysfunction syndrome only.
. Patients who have previous surgery in TMJ.
. Patients who have previous arthrocentesis within 1 year.
. Patients with prosthetic joint replacement.
. Patients allergic to any components of the injecting solution.
. Patients who received previous trauma to the joint.

What they're measuring

Maximum mouth opening

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Lateral to Right movement

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Lateral to Left movement

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Protrusive movement

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Joint Clicking

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively

Joint Pain

Timeframe: immediate preoperative then 1, 3 and 6 months postoperatively