Effects of Dietary Supplements on Nail and Hair Health (NCT07373574) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Dietary Supplements on Nail and Hair Health
90 participantsStarted 2026-06-01
Plain-language summary
This is a research study conducted by Standard Process, Inc. and the University of North Carolina and Chapel Hill Nutrition Research Institute, which aims to evaluate the effectiveness of nutritional supplementation in improving the health of fingernails and hair.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Healthy female and male adults who are 18 to 75 years of age (inclusive)
. Display longitudinal (vertical) nail ridges in the absence of other nail abnormalities
. No cosmetic nail treatments that would mask the natural appearance of the nail plate in the past 6 months (i.e., manicure procedures that smooth the nail surface, nail polish)
. In good general health (no uncontrolled diseases or conditions) as deemed by the investigator and is able to consume the study product
. Individuals with childbearing potential must agree to practice an acceptable form of birth control for a certain timeframe prior to the first dose of study product and throughout the study, including:
. use for at least 3 months prior to the first dose of study product: hormonal contraceptives including oral contraceptives, hormone birth control patch (e.g., Ortho Evra), vaginal contra-ceptive ring (e.g., NuvaRing), injectable contraceptives (e.g., Depo-Provera, Lunelle), or hormone implant (e.g., Norplant System), or intrauterine devices (e.g., Mirena); or
. use for at least 1 month prior to the first dose of study product: double-barrier method, non-hormonal intrauterine devices (i.e., copper), or complete abstinence from sexual inter-course that may result in pregnancy; or
. vasectomy of partner at least 6 months prior to the first dose of study product Individuals with the potential to impregnate others must agree to use condoms or other acceptable methods to prevent pregnancy throughout the study. Complete abstinence from sexual intercourse that may result in pregnancy is also acceptable.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing dietary supplements for nail and hair health and it hasn't started enrolling yet — given that timing, do you think it's worth me waiting to see if I can participate, or is there something I could try now in the meantime?
2The study compares two test products against an 'active control' supplement over 6 months — do you know what's actually in these products, and are any of those ingredients something you'd already recommend or be cautious about for my specific health situation?
3Since this trial focuses on nutrient intake and nutrient inadequacy, would you suggest I first get bloodwork done to see if I actually have any nutritional deficiencies that might be driving my nail or hair concerns?
4The trial is measuring nail ridge patterns and the biochemical composition of nails after 6 months — is that kind of outcome something that would be meaningful for my situation, or are my symptoms more likely related to something the study isn't designed to address?
5Because this study is listed as 'Phase NA,' meaning it's not a drug trial in the traditional sense, what should I understand about how the safety and effectiveness of these supplements would be evaluated compared to a standard pharmaceutical study?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Determine the effects of test products (TP1/2) versus active control (AC) on numbers and severity of longitudinal (vertical) nail ridges
Timeframe: 6 months
2
Determine the effects of TP1/2 versus AC on nail biostructure and biochemical composition after 6 months of supplementation
. Individuals who are lactating, pregnant or planning to become pregnant during the study as con-firmed at the baseline visit (Visit 2)
. Individuals who have applied cosmetic/topical treatments to fingernails in the past 6 months (i.e., manicures with nail plate filing, nail polish)
. Individuals who display nail abnormalities indicative of a health condition affecting nail appearance or have been diagnosed with a disease affecting nails (i.e., thickening, discoloration, horizontal nail ridges \[Beau's lines\])
. Individuals with active nail biting (onychophagia) or other behaviors that may affect nail integrity
. Have a known sensitivity, intolerability, or allergy to any of the study products or their excipients
. Currently has COVID-19 or tests positive for COVID-19 within 28 days prior to baseline visit
. Individuals opposed to consuming animal products
. Have a history of uncontrolled hypertension (140/90 or greater mmHg), kidney dysfunction or dis-ease (dialysis or renal failure), hepatic impairment or disease