CompletedNot Applicable

Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial

China120 participantsStarted 2025-10-01

Plain-language summary

to investigate whether oliceridine is safe and effective for induction of anesthesia by comparing henodynamic changes before and after endotracheal intubation with sufentanil

Who can participate

Age range18 Years – 65 Years

SexFEMALE

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Inclusion criteria

✓. Age 18-65 years;
✓. American Society of Anesthesiologists (ASA) physical status I-II;
✓. Elective gynecologic laparoscopic surgery;
✓. Expected operative time 60-180 minutes;

Exclusion criteria

✕. Severe cardiovascular instability (e.g., acute decompensated heart failure, acute myocardial infarction, or life-threatening arrhythmia);
✕. Uncontrolled hypertension;
✕. Severe renal or hepatic dysfunction;
✕. Severe mental disorder or psychiatric illness;
✕. Known allergy or hypersensitivity to opioids;
✕. History of alcohol abuse or opioid addiction;
✕. Anticipated difficult airway;
✕. Pregnancy or lactation;

What they're measuring

blood pressure

Timeframe: baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation

heart beat

Timeframe: baseline, at the moment of intubation, right after intubation, 1 minute、3 minutes, and 5 minutes after intubation

Trial details

NCT IDNCT07372209

SponsorTangshan Maternal and Child Health Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-15

View on ClinicalTrials.gov More Gynecological Laparoscopic Surgery trials