Active — Not RecruitingPhase 4

A Comparative Analysis of the Effectiveness of Nepafenac Combined With a Lubricant Versus a Lubricant Alone in the Treatment of Epiphora Associated With Lacrimal Punctum Stenosis

Mexico68 participantsStarted 2026-01-12

Plain-language summary

Establish the efficacy of combined treatment with nepafenac and lubricant versus lubricant alone in improving epiphora and resolving punctal stenosis in Mexican adults.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of epiphora secondary to lacrimal punctum stenosis of allergic or idiopathic origin. Age ≥ 18 years Exclusion Criteria: * Previous eye surgery, including eyelid or lacrimal duct surgery. Allergy to nepafenac. Previous application of botulinum toxin to the eyelids, medical treatment received at least 3 months prior to the study, treatment discontinuation, failure to attend scheduled follow-up appointments and severe adverse reactions to treatment.

What they're measuring

Lacrimal punctal estenosis

Timeframe: From enrollment to the end, each month of treatment until 8 weeks

Epiphora

Timeframe: From enrollment to the end, each month of treatment until 8 weeks

Trial details

NCT IDNCT07372014

SponsorInstituto de Oftalmología Fundación Conde de Valenciana

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-03-02

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