CompletedNot Applicable

The Effect Of Positive End-Expiratory Pressure on Optic Nerve Sheath Diameter In Pediatric Patients Undergoing Craniotomy in Supine Position

Turkey (Türkiye)30 participantsStarted 2021-01-01

Plain-language summary

This study evaluated the effect of positive end-expiratory pressure (PEEP) on optic nerve sheath diameter (ONSD), an indicator of intracranial pressure, in pediatric patients undergoing craniotomy in the supine position. The findings indicated that the application of PEEP did not result in a significant difference in ONSD. Although a significant decrease in systolic and diastolic blood pressure was observed with the use of PEEP, these values remained within normal ranges and did not indicate adverse hemodynamic effects. The results suggest that the use of a PEEP level of 4 cmH2O in pediatric patients with intracranial masses is safe and may be applied during the perioperative period.

Who can participate

Age range6 Months – 18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pediatric patients aged 6 months to 18 years * American Society of Anesthesiologists (ASA) physical status III * Scheduled for elective craniotomy in the supine position * Presence of an extra-axial intracranial mass * Written informed consent obtained from parents or legal guardians Exclusion Criteria: * Open fontanelles * Orbital pathology * Severe increases in intracranial pressure associated with nausea, vomiting, visual disturbances, or seizures * Radiologic or clinical signs of brain herniation * Hydrocephalus * Cerebral infection * Congenital syndromes * History of surgery involving the optic nerve * Use of inotropic therapy * Hemodynamic instability * Surgical complications during the operation or procedures lasting longer than 8 hours * Postoperative intubation requiring intensive care unit follow-up * Tumors invading the optic nerve * Inability to obtain written informed consent from parents or legal guardians

What they're measuring

optic nerve sheath diameter

Timeframe: Four times in during the operation by using ultrasonography. T0: before induction of anesthesia; T1: immediately after the dura was opened; T2: just before the dura was closed; T3: before extubation

Trial details

NCT IDNCT07370779

SponsorDr. Lutfi Kirdar Kartal Training and Research Hospital

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2021-10-30