RecruitingNot Applicable

Environmental Reservoirs of Non-tuberculous Mycobacteria in Cystic Fibrosis Households: A Case-control Study of Exposure Risk at Home

Germany120 participantsStarted 2026-01

Plain-language summary

This multicenter, non-interventional case-control study investigates whether household environmental reservoirs, particularly water systems, are associated with non-tuberculous mycobacterial (NTM) infections in people with cystic fibrosis. Environmental samples from the homes of CF patients with and without NTM infection will be analyzed and genetically compared with available clinical isolates, alongside assessment of environmental risk factors, to improve understanding of exposure pathways and inform future prevention strategies.

Who can participate

SexALL

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Inclusion Criteria: * Confirmed diagnosis of cystic fibrosis (CF) * No age restriction (including minors with consent from legal guardians) * Written informed consent to participate in the study (or consent provided by a legal guardian for minors) * In the case of an NTM infection: diagnosis according to ATS/IDSA criteria and availability of a clinical NTM isolate Exclusion Criteria: * Lack of capacity to provide informed consent, refusal to participate, or withdrawal of informed consent

What they're measuring

Prevalence of NTM in environmental samples

Timeframe: 2030

Difference in NTM prevalence between case and control groups

Timeframe: 2030

Genetic concordance between environmental and patient isolates

Timeframe: 2030

Trial details

NCT IDNCT07369414

SponsorResearch Center Borstel

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2028-12

Contact for this trial

Margo Diricks, PhD

+49 4537 / 188-7540 mdiricks@fz-borstel.de

View on ClinicalTrials.gov More Cystic Fibrosis (CF) trials