CompletedNot Applicable

Elective Total Abdominal Hysterectomy With Preoperative Analgesia Intravenous Paracetamol Versus Placebo

Thailand40 participantsStarted 2024-10-10

Plain-language summary

The study aim to study to evaluate whether IV paracetamol reduces morphine use after TAH. Primary objective was to compare postoperative morphine consumption between the IV paracetamol and control groups. and Secondary objective was to compare postoperative pain scores using the Numeric Rating Scale OR NRS

Who can participate

Age range30 Years – 50 Years

SexFEMALE

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Inclusion criteria

✓. Female patients aged 30-50 years.
✓. Scheduled to undergo total abdominal hysterectomy (TAH) at Queen Savang Vadhana Memorial Hospital at Sriracha
✓. No history of allergy to paracetamol (acetaminophen) or morphine.
✓. Normal renal function: serum creatinine ≤ 1.2 mg/dL.
✓. No severe or recurrent liver disease, and AST or ALT ≤ 3× the upper limit of normal.
✓. Able to communicate in Thai, complete the questionnaire, and provide written informed consent (no restriction on race or nationality).

Exclusion criteria

✕. Incomplete medical record.
✕. Use of any analgesic medications within 24 hours preoperatively.
✕. Receipt of any postoperative analgesic other than morphine during the first 24 hours after surgery.
✕. Withdrawal from the study.
✕. Adverse reaction after administration of the study drug.
✕. Concomitant surgery involving other organs (e.g., ovary or lymph nodes).

What they're measuring

Compare postoperative morphine consumption between the IV paracetamol and control groups.

Timeframe: at 1, 6, 12, and 24 hours postoperation

Trial details

NCT IDNCT07368790

SponsorQueen Savang Vadhana Memorial Hospital, Thailand

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-20

View on ClinicalTrials.gov More Postoperative Pain trials