In primary adrenal insufficiency (PAI), there is a risk of hypoglycemia and dehydration. These risks seem to be increased during intermittent fasting. A previous study in patients with PAI treated with hydrocortisone at a dose of 20 mg/day showed that the prevalence of hypoglycemia was as high outside (63%) as during Ramadan fasting (71%), and that there was no risk of dehydration. We propose to evaluate the risk of complications during and outside of Ramadan fasting through a prospective study with subjects taken as their own controls, in 35 patients with PAI treated with prednisolone at a dose of 5 mg/day. Patients will undergo an interview, physical examination, blood sampling, and continuous glucose monitoring (CGM) during two weeks of fasting and two weeks of non-fasting.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Hypoglycemia
Timeframe: during 14 days before Ramdan fasting and 14 days of Ramdan fasting
Dehydration
Timeframe: During the 14 days before Ramadan fasting and during the 14 days of Ramadan fasting.