RecruitingNot Applicable

Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status

Turkey (Türkiye)102 participantsStarted 2025-12-20

Plain-language summary

Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales.

Who can participate

Age range40 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosed with Knee OA according to ACR criteria. * Knee pain for more than 3 months. * Voluntary participation. Exclusion Criteria: * History of surgical intervention in the affected knee. * History of trauma to the affected knee within the last 6 months. * History of intra-articular injections (e.g., corticosteroids, hyaluronic acid, PRP) or physical therapy involving the affected knee within the last 6 months. * Presence of severe psychiatric disorders such as severe depression, anxiety disorder, or psychosis. * Diagnosis of central nervous system diseases, including Parkinson's disease or multiple sclerosis. * Diagnosis of inflammatory arthritis, such as Rheumatoid Arthritis or Ankylosing Spondylitis. * Severe cognitive impairment. * Chronic decompensated cardiac, renal, or hepatic failure. * Severe psychiatric, neurological, or kognitive disorders. Decompensated cardiac, renal, or hepatic failure.

What they're measuring

Visual Analog Scale (VAS)

Timeframe: at baseline assessment

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Timeframe: at baseline assessment

Trial details

NCT IDNCT07367126

SponsorIstanbul Physical Medicine Rehabilitation Training and Research Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2026-03-31

Contact for this trial

Eser Kalaoglu, M.D.

+90 (212) 496 50 00 eserkalaoglu@hotmail.com