Effect of Combined Adductor Canal and AFCN Block on Postoperative Inflammation

Inclusion Criteria: * • Patients scheduled for elective unilateral total knee arthroplasty under spinal anesthesia * Aged 18 years and older * Body mass index (BMI) \<40 kg/m² * ASA physical status I-III * Provision of written informed consent Exclusion Criteria:• Emergency surgery * Revision or bilateral surgery * General anesthesia or conversion to general anesthesia due to failed block * BMI ≥40 kg/m² * ASA physical status \>III * Local infection, hematoma, previous surgery, or deformity at the block site * Coagulopathy or history of hematologic, renal, or hepatic disease; advanced respiratory or cardiac failure; malignancy * Use of anticoagulant therapy * History of local anesthetic allergy or toxicity * Impaired cooperation, Alzheimer's disease, dementia, psychiatric or neurological disorders, or language/communication barriers * Chronic analgesic use, chronic alcohol consumption, or substance abuse * Refusal to participate in the study