Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With A… (NCT07366684) | Clinical Trial Compass
RecruitingNot Applicable
Clinical Characteristics, Frailty, and Prognostic Predictors in Patients Aged 75 and Older With Acute Coronary Syndrome
Serbia550 participantsStarted 2026-05-13
Plain-language summary
This study will evaluate clinical characteristics, frailty, and predictors of prognosis in patients aged 75 years and older who are hospitalized with acute coronary syndrome (ACS). The research includes both a retrospective and a prospective cohort. The aim is to determine whether frailty scores, combined with clinical and laboratory parameters available at admission, can improve risk prediction for complications and mortality compared with standard risk scores (TIMI, GRACE, Syntax). The study will also compare outcomes between patients treated with percutaneous coronary intervention (PCI) and those treated conservatively with medications. Patients will be followed during hospitalization and for six months after discharge. The results are expected to contribute to more personalized treatment strategies for elderly patients with ACS.
Who can participate
Age range
75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 75 years
* Diagnosis of acute coronary syndrome (STEMI, NSTEMI, or unstable angina)
* Hospitalization in a tertiary care center (University Clinical Center Niš)
* For prospective cohort: signed informed consent
Exclusion Criteria:
* Refusal to provide informed consent (prospective cohort)
* Missing or incomplete medical documentation (retrospective cohort)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this study is specifically looking at patients 75 and older with heart attacks or unstable angina, would I be a good candidate to participate, and what would my involvement actually require day-to-day?
2This trial is comparing a procedure like PCI — where they open blocked arteries — against more conservative medication-based treatment in older patients; based on my specific situation, which approach is my doctor already leaning toward, and how might joining this study affect that decision?
3The study is tracking deaths and major events like stroke and heart attack over time in elderly ACS patients — does participating mean I would receive any different treatment than I'd get outside the study, or would my care plan stay the same regardless?
4Since frailty is one of the things being measured in this trial, how does my doctor assess my frailty level, and how might that assessment influence which treatment strategy they'd recommend for me?
5Are there standard treatment guidelines already in place for someone my age with this type of heart condition that my doctor would recommend first, or is this study filling a genuine gap in what's known about treating older patients like me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Impact of treatment strategy (PCI vs conservative therapy) on on all-cause mortality and major adverse cardiovascular events (MACE: cardiovascular death, myocardial infarction, stroke) in elderly patients with acute coronary syndrome (ACS)
Timeframe: Peri-procedurally (within 48 hours of PCI or index admission for conservative therapy), at discharge (assessed up to 14 days after admission (Day 1)), and at 6 months after discharge (± 14 days).