Autologous Transplantation of Human Cryopreserved Testis Tissue (NCT07364409) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Autologous Transplantation of Human Cryopreserved Testis Tissue
Denmark5 participantsStarted 2024-11-04
Plain-language summary
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility. This experimental clinical study aims to provide proof-of-concept that frozen-thawed, ectopically autotransplanted adult human testicular tissue can support spermatogenesis in healthy adult men.
Who can participate
Age range
40 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Men referred to the Department of Urology at Herlev and Gentofte Hospital for the treatment of hydrocele or spermatocele were provided with detailed information about the study and invited to participate. Written study information was distributed, and a mandatory reflection period of at least 24 hours was observed prior to obtaining consent.
Inclusion Criteria:
* Age ≥ 40 years
* Scheduled for an elective hydrocele or spermatocele surgery
* Willing to have a testis biopsy taken during the planned surgery
* At least one biological child, unassisted spontaneous conception
* No current or future fertility wishes
* Written informed consent for the participation in this study
Exclusion Criteria:
* Treatment with testosterone substitution
* Bleeding disorders that render surgery too high a risk
* Other contraindications to surgery
* Unable to give informed consent
* Language difficulties that could compromise the informed consent or quality of examination
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Sperm retrieval
Timeframe: Sperm retrieved yes/no at 6 months post transplantation