CompletedNot Applicable

Impact of Preserving Versus Ligating the Right Gastric Artery on Anastomotic Outcomes After McKeown Esophagectomy: A Randomized Controlled Trial

China120 participantsStarted 2018-06-01

Plain-language summary

This randomized controlled trial evaluates the impact of preserving versus ligating the Right Gastric Artery (RGA) on postoperative anastomotic complications in patients undergoing McKeown minimally invasive esophagectomy (MIE) for esophageal squamous cell carcinoma. Specifically, the study compares the incidence of anastomotic leakage and stenosis between two groups of patients reconstructed with a 3cm-wide gastric conduit.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Histologically confirmed squamous cell carcinoma of the middle or upper thoracic esophagus. * Candidates for elective McKeown minimally invasive esophagectomy (MIE). * Age 18-75 years. * Preoperative clinical stage I-IIIA (cT1-3N0-1M0) according to the AJCC/UICC 8th Edition TNM staging system. Exclusion Criteria: * Clinical stage IIIB or IV. * History of previous thoracic or abdominal surgery affecting the stomach or esophagus. * Neoadjuvant chemoradiotherapy (to eliminate confounding effects on tissue healing). * Severe comorbidities (e.g., uncontrolled diabetes, severe cardiopulmonary dysfunction, liver cirrhosis). * Intraoperative finding of unresectable tumor. * Conversion to open surgery.

What they're measuring

Incidence of Cervical Anastomotic Leakage

Timeframe: Up to 30 days postoperatively

Incidence of Anastomotic Stenosis (Early)

Timeframe: 2 months postoperatively

Incidence of Anastomotic Stenosis (Late)

Timeframe: 4 months postoperatively

Trial details

NCT IDNCT07363629

SponsorThe First Hospital of Hebei Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-07-31