Active — Not RecruitingNot Applicable

TMS-Induced LH Response in Healthy Women in Luteal Phase

United States10 participantsStarted 2026-02-24

Plain-language summary

The purpose of this research is to establish whether non-invasive Transcranial Magnetic Stimulation (TMS), can affect modulation of hormones such: Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH). The hypothesis is that applying TMS to the Dorsolateral Prefrontal Cortex with specific pulse patterns, mimicking endogenous Gonodotropin-Releasing Hormone (GnRH) pulses that are known to stimulate LH secretion may modulate hormonal levels.

Who can participate

Age range

22 Years – 40 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy women aged 22-40 years with regular menstrual cycle. * In luteal phase at the time of visit. Exclusion Criteria: * Presence of any known structural brain abnormalities or tumors. * Presence of metal implants/devices in the head or neck. * Has ever had a stroke, seizure, or has a family history of epilepsy. * Head injury with loss of consciousness. * Use of hormonal contraceptives in the past 3 months. * Irregular menstrual cycles. * Diagnosed with a reproductive system disorder (e.g., PCOS, endometriosis, infertility, hypogonadism). * History of endocrine disorders such diabetes mellitus, thyroid disease, adrenal disorders, pituitary tumor or others. * Been diagnosed or received treatment for depression, anxiety disorder, schizophrenia, PTSD or bipolar disorder. * Have a history of medical disorder such liver or renal impairment, HIV/AIDS or unstable cardiac disease. * Taking any medications that affect the central nervous system such as antidepressents, antipsychotics, GLP-1 receptor agonists or hormone therapies. * Are you pregnant, planning pregnancy or breastfeeding. * Have experienced difficulties in the past during blood draws such as locating the vein, fainting or other adverse reactions. * Have any sleep disorder such as insomnia or sleep apnea. * Have fear of needles or the sight of blood. * Underwent TMS stimulation in the past and had difficulties.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels

Timeframe: Six blood draws per participant: Baseline 1 (30 minutes pre-TMS), Baseline 2 (immediately pre-TMS), T1 (20 minutes post-TMS), T2 (55 minutes post-TMS), T3 (20 minutes post-second TMS), T4 (55 minutes pos-second TMS).

Trial details

NCT IDNCT07363421

SponsorThe City College of New York

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-01

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