Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache (NCT07360782) | Clinical Trial Compass
RecruitingNot Applicable
Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache
Turkey (Türkiye)90 participantsStarted 2026-01-26
Plain-language summary
This study evaluates a novel treatment approach for medication overuse headache (MOH) using greater occipital nerve pulsed radiofrequency (GONPRF).
Three treatment strategies are compared:
Standard Treatment: Limitation of overused acute headache medications, lifestyle counseling, and continuation of existing preventive medications.
Primary GONPRF: GONPRF administered in addition to standard treatment.
Modified GONPRF: GONPRF administered as a second-line intervention in individuals who do not respond adequately to standard treatment alone.
The study assesses whether GONPRF, when applied early or after an initial period of standard care, reduces monthly headache days more rapidly and effectively than standard treatment alone. Outcomes are evaluated over a 6-month follow-up period using headache diaries and scheduled clinical assessments.
This is a randomized controlled trial designed to systematically evaluate the clinical benefit of GONPRF in patients with medication overuse headache.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Age 18-65 years
* Diagnosed with Medication Overuse Headache (MOH) according to ICHD-3 criteria
* No laboratory evidence of bleeding or clotting disorders
* No active infection
* Not pregnant and no suspicion of pregnancy
* No history of craniocervical surgery that may alter anatomical structures at the intervention site
* Able to understand the study procedures, provide written informed consent, and comply with treatment
Exclusion Criteria
* Changes in preventive treatment for migraine and/or tension-type headache within the last 3 months
* Severe systemic disease (e.g., uncontrolled diabetes, serious cardiovascular disease, malignancy)
* Psychiatric disorders (including current antidepressant use or psychiatric follow-up)
* History of alcohol or substance abuse
* Pregnancy, breastfeeding, or plans for pregnancy in the next 12 months
* Concurrent use of other prophylactic headache treatments
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.