The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St. Thomas' cold crystalloid cardioplegia, Calafiore warm blood cardioplegia, or modified del Nido cold blood cardioplegia in routine coronary artery bypass grafting procedures.
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Changes in extracellular vesicles-derived miRNAs as markers of myocardial injury
Timeframe: From start of surgery and for 24 hours
Changes in complement system activation
Timeframe: from start of surgery and for 24 hours
Changes in neutrophil extracellular traps (NETs)
Timeframe: From start of surgery and for 24 hours