Serum Progesterone and Threatened Abortion During Lactation (NCT07357922) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Serum Progesterone and Threatened Abortion During Lactation
150 participantsStarted 2026-01-01
Plain-language summary
This study aims to evaluate the effect of first-trimester maternal serum progesterone levels on threatened abortion in women who conceive during the lactation period. Serum progesterone concentrations will be measured in lactating pregnant women during the first trimester, and their association with the etiology of threatened abortion will be analyzed.
Threatened abortion is defined as vaginal bleeding occurring in the first trimester of pregnancy and represents a risk for early pregnancy loss. Previous studies have shown that serum progesterone levels may be lower in cases of threatened abortion compared to healthy pregnancies and play an essential role in predicting miscarriage risk. Serum progesterone is therefore considered a useful biomarker for assessing pregnancy viability and prognosis.
During lactation, progesterone levels may vary depending on breastfeeding duration and maternal hormonal status, and generally remain low, similar to follicular-phase levels in non-pregnant women. However, normal reference values during lactation are not well established. This study aims to contribute new data to the limited literature on the relationship between lactation, serum progesterone levels, and threatened abortion, and to provide insights that may help improve early pregnancy loss prevention strategies.
Who can participate
Age range
18 Years – 50 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female participants aged 18 to 50 years.
* Pregnant women who conceived during the lactation period.
* Singleton pregnancy.
* First-trimester pregnancy.
* Availability of first-trimester serum progesterone measurement obtained as part of routine antenatal care.
* Ongoing follow-up at the participating hospitals.
Exclusion Criteria:
* Age under 18 years or over 50 years.
* Multiple pregnancies.
* Known chronic medical diseases.
* Use of progesterone supplementation before serum progesterone measurement.
* Missing or incomplete clinical or laboratory data.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is specifically looking at threatened abortion in women who are breastfeeding while pregnant — does my situation fit that profile, and is that something worth discussing as a potential option when the trial opens?
2Since this trial hasn't started recruiting yet, how long might it realistically be before I could even be considered for it, and what should I be doing in the meantime to manage my situation?
3The trial is measuring how often threatened abortion occurs in lactating pregnant women — does that mean it's primarily an observational study tracking what happens rather than testing a new treatment, and what would that mean for me practically?
4Progesterone is already used in some cases of threatened abortion — is there a standard progesterone-based treatment my doctor could offer me now, rather than waiting for this trial to begin?
5Given that this study is still in the planning phase with no assigned phase designation, what is actually known about the relationship between breastfeeding, progesterone levels, and pregnancy loss that I should understand before considering any next steps?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of Threatened Abortion in Lactating Pregnant Women
Timeframe: From enrollment in the first trimester until 14 weeks of gestation
Trial details
NCT IDNCT07357922
SponsorProf. Dr. Cemil Tascıoglu Education and Research Hospital Organization