RecruitingNot Applicable

Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery

Turkey (Türkiye)70 participantsStarted 2026-01-14

Plain-language summary

This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients undergoing supratentorial surgery. Propofol and remifentanil are administered using either target-controlled or manual infusion techniques according to the study protocol. Secondary objectives include comparisons of intraoperative anesthetic consumption, hemodynamic responses, recovery profiles, postoperative pain, and postoperative nausea and vomiting between the two anesthesia strategies. The study seeks to evaluate whether target-controlled infusion provides improved anesthetic management and postoperative outcomes compared with manual total intravenous anesthesia.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients aged 18 to 60 years * Scheduled for elective supratentorial surgery under general anesthesia * American Society of Anesthesiologists (ASA) physical status I or II * Planned total intravenous anesthesia with propofol and remifentanil * Ability to provide written informed consent Exclusion Criteria: * Refusal or inability to provide written informed consent * American Society of Anesthesiologists (ASA) physical status III or higher * Pregnancy * Emergency surgery * Presence of brain herniation * Anticipated or documented difficult airway * Inability to communicate effectively (e.g., non-Turkish speaking or hearing impairment) * Preoperative risk factors for delirium, including substance abuse, use of neuropsychiatric medications, preoperative hemoglobin level \< 8 g/dL, malnutrition, or electrolyte or thyroid hormone abnormalities * Intraoperative deviation from the study protocol, including changes in surgical or anesthetic technique or occurrence of major intraoperative complications * Contraindications to propofol or remifentanil

What they're measuring

Incidence of Postoperative Delirium

Timeframe: Postoperative 72 hours

Trial details

NCT IDNCT07357480

SponsorIstanbul University - Cerrahpasa

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05

Contact for this trial

Ali Okuyan, MD

+905073736874 aliokuyan@gmail.com