Evaluating Suzetrigine for Pain Control Following TKA (NCT07357376) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Evaluating Suzetrigine for Pain Control Following TKA
210 participantsStarted 2026-03-01
Plain-language summary
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine works to treat pain after total knee replacement surgery in adults. It will also learn about the safety of suzetrigine. The main questions it aims to answer are:
Does suzetrigine lower the amount of opioid pain medicine participants use after surgery?
Does suzetrigine have any effect on postoperative patient-reported outcomes, including pain scores, range of motion, length of stay, and KOOS/PROMIS surveys?
Researchers will compare suzetrigine to a placebo to see if suzetrigine works to treat pain after total knee replacement surgery.
Participants will:
Take suzetrigine or a placebo by mouth for 14 days after surgery
Receive standard pain care, including opioid pain medicine only if needed
Report their pain levels using short daily surveys
Attend routine follow-up visits after surgery
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* Scheduled for elective, unilateral primary total knee arthroplasty
* Able to tolerate oral medications after surgery
Exclusion Criteria:
* Revision or bilateral total knee arthroplasty
* American Society of Anesthesiologists (ASA) physical status classification greater than 3
* Severe renal impairment (estimated glomerular filtration rate less than 15 mL/min/1.73 m²)
* Severe hepatic impairment (Child-Pugh Class C)
* Chronic opioid use of 30 morphine milligram equivalents per day or greater for more than 3 months
* Pregnancy or breastfeeding
* Seizure disorder or known hypersensitivity to suzetrigine
* Use of medications contraindicated with CYP3A metabolism
* Active gastrointestinal ulcer or bleeding
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.