Comparison Between Two Instrumentation Techniques on Postoperative Pain and Level of Neuropeptides (NCT07357233) | Clinical Trial Compass
RecruitingNot Applicable
Comparison Between Two Instrumentation Techniques on Postoperative Pain and Level of Neuropeptides
Egypt34 participantsStarted 2025-09-01
Plain-language summary
General aim: assessment of post operative pain and time of preparation with the execution of manual-less technique and conventional technique.
Specific aim: correlation between post operative pain and release of Substance P and Calcitonin gene-related peptide.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Patients with symptomatic irreversible pulpitis and apical periodontitis in mandibular molars with closed apex.(17)
. Healthy males and females (Category: American Society of Anesthesiologists class I).
. Age of patients range from 18 to 50 years old.
. Those who could understand the use of the numeric rating scale (NRS) for pain.
. In cases where radiographs show no root resorption or abnormal anatomy.
. Patients with good oral hygiene and free from periodontal diseases.
Exclusion criteria
. Allergy to anesthetics.
. Pregnancy
. Unrestorable teeth.
. Patient on analgesics.
. Prescence of root resorption or abnormal anatomy.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.