RecruitingNot Applicable

Comparison Between Two Instrumentation Techniques on Postoperative Pain and Level of Neuropeptides

Egypt34 participantsStarted 2025-09-01

Plain-language summary

General aim: assessment of post operative pain and time of preparation with the execution of manual-less technique and conventional technique. Specific aim: correlation between post operative pain and release of Substance P and Calcitonin gene-related peptide.

Who can participate

Age range18 Years – 50 Years

SexALL

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Inclusion criteria

✓. Patients with symptomatic irreversible pulpitis and apical periodontitis in mandibular molars with closed apex.(17)
✓. Healthy males and females (Category: American Society of Anesthesiologists class I).
✓. Age of patients range from 18 to 50 years old.
✓. Those who could understand the use of the numeric rating scale (NRS) for pain.
✓. In cases where radiographs show no root resorption or abnormal anatomy.
✓. Patients with good oral hygiene and free from periodontal diseases.

Exclusion criteria

✕. Allergy to anesthetics.
✕. Pregnancy
✕. Unrestorable teeth.
✕. Patient on analgesics.
✕. Prescence of root resorption or abnormal anatomy.

What they're measuring

Change in post operative pain

Timeframe: 6 hours,12 hours,24 hours,48 hours,72 hours

Trial details

NCT IDNCT07357233

SponsorAlexandria University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-02-01

Contact for this trial

hamdy Abou Almakarem, Msc

01273805931 hamdy.elwan.dent@alexu.edu.eg

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