CompletedNot Applicable

Metabolic Flexibility and Metabolic Heath in Human Obesity

Chile74 participantsStarted 2022-09-23

Plain-language summary

This interventional study explores the relationship between improvements in metabolic health following weight loss and changes in whole-body fat mass and its distribution. The study focuses on adult men and women with excess body weight undergoing dietary energy restriction over 12 weeks. The primary research question is: Does a greater reduction in fat mass for a given weight loss correlate with more significant improvements in metabolic health?

Who can participate

Age range30 Years – 55 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria * males or females * 30-55 y old * physically inactive (\<600 MET´min/wk of self-reported moderate-vigorous physical activity * stable body weight for at least the past 6 months (±2 kg) * healthy according to medical history and routine hematology and biochemistry. Exclusion criteria * Individuals with physiological (pregnancy, lactation) or pathological (under drug therapy for and/or having cardiovascular, liver, kidney, thyroid diseases) * conditions affecting energy metabolism or eating behavior * Subjects having low-fat (\<20% energy) or low-carbohydrate (\<45% energy) diets * Smokers and alcohol abusers

What they're measuring

Fasting serum triglyceride concentration

Timeframe: From enrollment to the end of weight maintenance period at 15-20 weeks

Trial details

NCT IDNCT07355933

SponsorJose Galgani

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-01-06

View on ClinicalTrials.gov More Obesity trials