Peri-Implant Sulcus Fluid Stress Markers in Health and Disease (NCT07353515) | Clinical Trial Compass
CompletedNot Applicable
Peri-Implant Sulcus Fluid Stress Markers in Health and Disease
Turkey (Türkiye)62 participantsStarted 2023-02-15
Plain-language summary
This study examines the association between psychosocial stress and peri-implant diseases. Peri-implant diseases are inflammatory conditions affecting the tissues around dental implants and may contribute to implant failure. Stress-related hormones, including cortisol and dehydroepiandrosterone (DHEA), may influence inflammatory responses in peri-implant tissues.
In this study, peri-implant sulcular fluid samples are collected from patients with peri-implant health, peri-implant mucositis, and peri-implantitis. Levels of cortisol, DHEA, and interleukin-6 (IL-6) are analyzed. Anxiety and depression levels are assessed using standardized questionnaires, and clinical peri-implant parameters are recorded.
The purpose of this study is to evaluate the relationship between stress-related biomarkers, psychological status, and peri-implant health and disease.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Being volunteer to participate in the study
* Adults aged 18 to 65 years.
* Systemically healthy individuals.
* No periodontal treatment within the past 6 months.
* No self-reported psychiatric disorders.
* No use of antibiotics within the past 6 months.
* No use of steroid, immunosuppressive, or psychiatric medications.
* No clinically evident oral infection.
* Not pregnant and not breastfeeding.
* Not smoking
* Maintaining oral hygiene
Exclusion Criteria:
* Age younger than 18 years or older than 65 years.
* History of periodontal treatment within the past 6 months.
* Use of antibiotics within the past 6 months.
* Inadequate or contaminated peri-implant sulcular fluid samples.
* Pregnancy or breastfeeding.
* Long-term corticosteroid usage.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.