PRP Plus Fractional CO₂ Laser for Acne Scars (NCT07352215) | Clinical Trial Compass
RecruitingNot Applicable
PRP Plus Fractional CO₂ Laser for Acne Scars
Pakistan70 participantsStarted 2025-10-31
Plain-language summary
This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart.
The primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \< 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:Adults aged 18 to 40 years
Male and female participants
Fitzpatrick skin types I to V
Presence of moderate-to-severe acne scars
Willing to undergo 3 treatment sessions and follow-up visits
Able to provide informed consent -
Exclusion Criteria:Use of topical anti-acne medications in the past 1 month
History of keloid formation or hypertrophic scarring
Active acne or active skin inflammation at treatment area
Diabetes mellitus
Photosensitive disorders (e.g., lupus, dermatomyositis)
Melasma
Active infections (e.g., Herpes simplex)
Recent laser resurfacing or similar procedures
Outdoor workers with high sun exposure
Vitiligo
Pregnancy or breastfeeding
Bleeding disorders or anticoagulant therapy
Unrealistic expectations or inability to comply with follow-up
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Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Acne Scar Severity (Goodman and Baron Quantitative Acne Scar Scale)
Timeframe: 12weeks
Trial details
NCT IDNCT07352215
SponsorGujranwala medical college District Headquarters Hospital, Gujranwala