CompletedPhase 3

Effects of Two Daily CHX Mouthrinses on Plaque, Gingivitis and Staining

Greece81 participantsStarted 2022-01-15

Plain-language summary

Τhe aim of this randomized clinical trial was to investigate the efficacy of two daily mouth rinses containing CHX and different combinations of H2O2 and CPC, when used adjunctive to mechanical oral hygiene, and compare them with a placebo mouth rinse. The primary outcomes evaluated were changes in i) bacterial biofilm accumulation, ii) gingival inflammation, and iii) tooth staining. Secondarily, patient's satisfaction and perspective after the use of these formulations was assessed.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients (≥18 years old) * Presence of at least 24 teeth * Presence of teeth #23-13 and #43-33 * Gingival Index (GI) ≤30% (Lindhe, 1981) * No interdental clinical attachment loss (CAL) at ≥2 non-adjacent teeth or buccal/oral CAL ≥3 mm with probing pocket depth (PPD) \>3 mm at ≥2 teeth (Tonetti et al., 2019) * No known allergy to chlorhexidine (CHX), hydrogen peroxide (H₂O₂), or cetylpyridinium chloride (CPC) * No fixed or removable orthodontic appliances or removable prostheses * No use of systemic antibiotics within the 3 months prior to the study * Non-smokers or light smokers (\<5 cigarettes/day) * Non-pregnant and non-lactating women * Absence of crowns, fixed partial dentures, or class III/IV/V composite restorations covering more than one-third of the crown, and no deep dental caries extending into dentine Exclusion Criteria: * Presented with signs of hypersensitivity, severe irritation, or discomfort during the experimental period * Were not compliant with the experimental protocol

What they're measuring

change in plaque index (PI)

Timeframe: baseline, 1 month, 2 months and 3 months

Trial details

NCT IDNCT07351370

SponsorDental School

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-07-20