Not Yet RecruitingPhase 4

Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

128 participantsStarted 2026-03

Plain-language summary

The purpose of this study is to determine if changing the type of anesthesia improves the outcomes of manipulation and pain control after the procedure. The study will compare a spinal anesthesia with a general anesthesia, to see if there is a better outcome from either anesthesia type.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Patients ≥18 years presenting for a manipulation of knee joint under anesthesia.
✓. ASA Classification I - III.
✓. English speaking patients.

Exclusion criteria

✕. ASA 4 or 5
✕. Daily chronic opioid use (over 3 months of continuous opioid use).
✕. Inability to communicate pain scores or need for analgesia.
✕. Infection at the site of block placement
✕. Age under 18 years old or greater than 75 years old
✕. Pregnant women (as determined by point-of-care serum bHCG)
✕. Intolerance/allergy to local anesthetics
✕. Weight \<50 kg

What they're measuring

Change in degrees of motion of the affected knee

Timeframe: At time of procedure completion

Trial details

NCT IDNCT07348614

SponsorDuke University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-08

View on ClinicalTrials.gov More Knee Stiffness After Total Knee Arthroplasty trials