Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Pro… (NCT07348510) | Clinical Trial Compass
RecruitingNot Applicable
Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures
Egypt106 participantsStarted 2026-01-17
Plain-language summary
This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion Criteria:
* Age from 18-65 years.
* Both sexes.
* All adult patients presenting for elective cardiac surgical procedures performed on cardiopulmonary bypass (Coronary artery bypass surgery, Cardiac valve repair and/or replacement, Repair of large septal defects, Repair and/or palliation of congenital heart defects, Transplantation, surgery of thoracic aneurysms.).
* Body mass index (BMI) ranged between 20 and 40 kg/m2.
Exclusion Criteria:
* Sensitivity or contraindication to Aminophylline or furosemide
* Stage-5 chronic kidney disease (CKD) \[Glomerular filtration rate (GFR) of less than 15 mL/min\].
* The presence of both factors (GFR less than 60 mL/min and albumin greater than 30 mg per gram of creatinine) along with abnormalities of kidney structure or function for greater than three months signifies chronic kidney disease.
* Recipients of dialysis before surgery.
* Recipients of solid-organ transplantation before surgery.
* Emergency cardiac surgical procedures (e.g. left main coronary artery bypass graft, stuck valves, etc).
* Patient refusal.