Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine Analogues

Inclusion Criteria: * Men or women, age 18 or older at screening who have used EC with nicotine during at least 10 of the past 30 days * Saliva cotinine concentration of \> 30 ng/mL at screening * Ability to communicate well with the investigator and to understand and comply with the requirements of the study * Women of child-bearing age engaging in sexual activities which can lead to pregnancy: willingness of using a reliable/hormonal contraception method during the study (hormonal, e.g. pill, intrauterine devices, or mechanical method, e.g. condom, diaphragm) * Signed informed consent form Exclusion Criteria: * Known hypersensitivity/allergy to a content of the e-liquids * Smoking of more than 5 cigarettes per day in the past 30 days * Pregnant or lactating women * Intention to become pregnant during the course of the study * BMI \< 18 or \> 30 kg/m2 at screening * History or clinical evidence of alcoholism or drug abuse within the 3-year period prior to screening * Loss of ≥ 250 mL of blood within 3 months prior to screening, including blood donation * Treatment with an investigational drug within 30 days prior to screening * Treatment with prescribed or over-the-counter medications with known influence on CYP2A6 function within 1 week prior to screening (with the exception of contraception) * History or clinical evidence of any disease (e.g. gastrointestinal tract-disease) and/or existence of any surgical or medical condition, which in the opinion of the investigator m…