Effect of Probiotics on Relapsing-Remitting Multiple Sclerosis (NCT07346924) | Clinical Trial Compass
CompletedNot Applicable
Effect of Probiotics on Relapsing-Remitting Multiple Sclerosis
Egypt60 participantsStarted 2024-01-01
Plain-language summary
This study aimed to assess the effect of probiotic supplementation on fatigue, quality of life, disability, depression and inflammatory markers in patients with relapsing-remitting multiple sclerosis (RRMS).
Patients were randomized to receive probiotics plus standard therapy The study sought to determine whether modulation of gut microbiota could provide additional clinical and immunological benefits in RRMS management.
Who can participate
Age range
20 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Clinically definite MS patients with a diagnosis of relapsing remitting multiple sclerosis according to revised McDonald criteria 2017.
* EDSS score of ≤ 4
Exclusion Criteria:
* Progressive MS either; primary progressive MS or secondary progressive MS
* Patients who had relapses and glucocorticoid therapy within the past 30 days.
* Pregnancy and women who were lactating within the prior six month
* Patients taking antibiotics
* History of gastroenteritis and bowel surgery over the past month, inflammatory bowel disease
* Presence of diabetes (type I \& type II) or diseases causing significant nutritional status impairment (malignancy, chronic infections)
* Patients who have changed their disease modifying drugs in the past 6 months prior to study
* Impaired cognition that limited ability to complete the questionnaires. Addiction to drugs or alcohol.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.