Dynamic 82-Rb Positron Emission Tomography (PET) for the Grading of KIDney Carcinoma (NCT07346404) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Dynamic 82-Rb Positron Emission Tomography (PET) for the Grading of KIDney Carcinoma
France50 participantsStarted 2026-01-01
Plain-language summary
This is a pilot prospective longitudinal monocentric, non-comparative, nonrandomised, and non-controlled open study.
is to test whether the intensity of 82-Rb uptake on PET acquisitions is associated to the aggressiveness of RCC on histology (ISUP grades), i.e., to successfully identify high-grade (ISUP grades 3 and 4) vs. lowgrade (ISUP grades 1 and 2) RCC.
Who can participate
Age range18 Years – 90 Years
SexALL
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Inclusion Criteria:
* Age ≥ 18 years old
* Signed written informed consent
* French Social Security affiliation
* Patients with high suspicion of or confirmed RCC requiring surgical resection
* Kidney tumor diameter between 2 cm and 7 cm with clear cell imaging feature (hyper vascular lesion with contrast-enhancement similar to the renal cortex on CTA)
* Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures
Exclusion Criteria:
* Pregnant or breastfeeding women
* Patient under legal protection (guardianship)
* Contraindication to the PET-CT
* Contraindication to the injection of 82-Rb
* Participation in another interventional study involving human participants or being in the exclusion period at the end of a previous study involving human participants, if applicable
* Patient on SMA (state medical aid)
* Unilateral renal agenesis
* Multicystic renal dysplasia
* Hereditary forms of RCC as VHL, MET, FH and FLCN
* Bosniak 3 cysts
* Hypovascular lesions with enhancement inferior to the renal cortex in corticomedullary-phase images on CTA
* Exclusion of clear renal cell adenocarcinoma on biopsy
* Kidney tumors with high suspicion of extra-renal extension (cT3b, cT3c, cN+ or M+).
What they're measuring
1
Classify the aggressiveness of RCC into low grade and high grade based on the 82-Rb uptake intensity in renal tumors on PET.