Not Yet RecruitingNot Applicable

Basilar Artery Occlusion Chinese Endovascular Registry in Patients With Large-Core Infarct

China518 participantsStarted 2026-01-31

Plain-language summary

This multicenter retrospective registry study evaluates the safety and effectiveness of endovascular therapy versus medical therapy for acute large-core basilar artery occlusion. It also investigates clinical, imaging, and laboratory factors associated with functional outcomes and mortality. Patients are grouped according to the treatment received in routine clinical practice.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age ≥18 years, men or women.
✓. Occlusion (TIMI 0-1) of the basilar artery or intracranial segments of both vertebral arteries (V4) as evidenced by CTA/MRA/DSA.
✓. Time from symptom onset (or last known well) to treatment (endovascular therapy or medical therapy) ≤7 days.
✓. Patients with large core infarction in the posterior circulation, defined as a posterior circulation Acute Stroke Prognosis Early CT score (pc-ASPECTS) score of 0-5 on CT angiography source images or MR with diffusion-weighted imaging or non-contrast CT.

Exclusion criteria

✕. Subjects with occlusions in both anterior and posterior circulation.
✕. CT or MR evidence of hemorrhage (the presence of microbleeds on MRI is allowed).
✕. Missing key clinical information (e.g., unavailable baseline NIHSS, unclear symptom onset/last known well time, or missing major treatment information including whether EVT was performed).
✕. Baseline NIHSS score \<6.
✕. Woman of childbearing potential who is known to be pregnant or lactating or who has a positive pregnancy test on admission.
✕. Missing follow-up outcomes at 90 days.
✕. Any other condition judged by investigators to substantially affect analysis or interpretation.

What they're measuring

Proportion of Patients Achieving mRS 0-3 at 90 Days

Timeframe: 90 days

Trial details

NCT IDNCT07345702

SponsorXuanwu Hospital, Beijing

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-10-31

Contact for this trial

Chuanhui Li

15210439828 lichuanhui@xwh.ccmu.edu.cn

View on ClinicalTrials.gov More Basilar Artery Occlusion trials