The Effects of Adjunctive Therapy With Vaginal Tablets Lactobacillus Acidophilus and a Low Dose Estriol (Gynoflor®) to Prolong Pregnancy Time in Preterm Labor, A Randomized Controlled Trial

Inclusion Criteria \- Pregnant women diagnosed with preterm labor or threatened preterm labor, with a gestational age between 24 and 33 weeks, who are receiving tocolytic therapy. Exclusion Criteria * Age under 18 years or 35 years and older * Incomplete course of Gynoflor® (less than 6 days of use) * Presence of contraindications to tocolysis * Preterm premature rupture of membranes (PPROM) * Unable to be contacted for follow-up * History of allergy to probiotics or Gynoflor® * Multiple gestation * History of short cervix diagnosed between 16-24 weeks of gestation * History of previous preterm labor (PTL) * Pregnancy achieved via assisted reproductive technology (ART) * Presence of fetal anomaly * History of antepartum hemorrhage * Substance abuse, including cigarette smoking, alcohol, cocaine, or heroin use * Other causes of preterm labor such as uterine overdistension (e.g., polyhydramnios, multifetal gestation), uterine abnormalities (e.g., myoma uteri), or systemic infections, except vaginitis