Not Yet RecruitingNot Applicable

Correcting Hypocapnia in Aneurysmal Subarachnoid Hemorrhage.

China80 participantsStarted 2026-01-01

Plain-language summary

Based on the clinical observation that over half of the patients in the management of aneurysmal subarachnoid hemorrhage(aSAH) present with spontaneous hyperventilation, which is significantly associated with delayed cerebral ischemia and poor neurological outcomes, this prospective pilot study is designed to investigate the safety and efficacy of normobaric facemask oxygen for hypocapnia in aSAH.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age \> 18 years.
✓. Confirmed diagnosis of aneurysmal subarachnoid hemorrhage (aSAH), with the presence of an aneurysm verified by computed tomography (CT), CT angiography (CTA), or digital subtraction angiography (DSA).
✓. Hunt-Hess grade II-IV.
✓. Presence of hypocapnia on arterial blood gas analysis, defined as PaCO2 \< 35 mmH;
✓. PaO2 \> 90 mmHg.

Exclusion criteria

✕. Presence of brain herniation or refractory intracranial hypertension, defined as a baseline intracranial pressure (ICP) \> 25 mmHg that responds poorly to conventional ICP-lowering therapy;
✕. Primary respiratory diseases (e.g., chronic obstructive pulmonary disease, severe asthma) known to cause chronically elevated baseline PaCO2;
✕. Severe acid-base disturbances other than respiratory alkalosis.
✕. Severe cardiac insufficiency, severe hepatic or renal dysfunction, malignant tumors, or other severe comorbidities that significantly impact prognosis;
✕. Before the onset of the disease, the mRS score was greater than 2, and there were other factors causing disability.
✕. Life expectancy \< 3 months;
✕. Any other condition deemed by the investigator to pose a high risk warranting exclusion.

What they're measuring

modified Rankin Scale (mRS) >3

Timeframe: 90-day follow-up visit

Incidence of delayed cerebral injury (DCI)

Timeframe: 30 days after onset

Trial details

NCT IDNCT07343232

SponsorThe Chinese University of Hong Kong, Shenzhen

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-09-30

Contact for this trial

Xinyu Yang, MD

18622766038 cuhkshzhyang@outlook.com

View on ClinicalTrials.gov More Aneurysmal Subarachnoid Hemorrhage (aSAH) trials