Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with overweight or obesity, even in the absence of dietary intake manipulation. Hybrid type training represents a form of HIIT, that incorporates both cardiorespiratory and musculoskeletal stimuli, by combining multiple types of exercise into a circuit-type, interval style workout. Recent evidence suggests that long-term participation in hybrid HIIT results in significant health-related benefits. However, the molecular mechanisms driving the chronic effects of hybrid HIIT on cardiometabolic and musculoskeletal health remains to be elucidated.
Age range
30 Years – 50 Years
Sex
ALL
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Change in mitochondrial size
Timeframe: At baseline and at 6 months
Change in mitochondrial density
Timeframe: At baseline and at 6 months
Change in mitochondrial count
Timeframe: At baseline and at 6 months
Change in mitochondrial distribution
Timeframe: At baseline and at 6 months
Change in maximum oxygen consumption (VO2max)
Timeframe: At baseline and at 6 months
Change in muscle fiber cross-sectional area
Timeframe: At baseline and at 6 months
Change in PAX7+ satellite cells count
Timeframe: At baseline and at 6 months
Change in total protein content
Timeframe: At baseline and at 6 months
Change in myonuclei content
Timeframe: At baseline and at 6 months
Change in peroxisome proliferator-activated receptor-gamma coactivator -1a (PGC-1a) expression
Timeframe: At baseline and at 6 months
Change in Krebs cycle (TCA cycle) enzymes activity
Timeframe: At baseline and at 6 months
Change in protein expression of respiratory chain complexes
Timeframe: At baseline and at 6 months
Change in cytochrome C oxidase amount and expression
Timeframe: At baseline and at 6 months
Change in ATP synthase amount and expression
Timeframe: At baseline and at 6 months
Change in citrate synthase amount and expression
Timeframe: At baseline and at 6 months
Change in succinate dehydrogenase amount and expression
Timeframe: At baseline and at 6 months
Change in NADH dehydrogenase amount and expression
Timeframe: At baseline and at 6 months
Change in mitochondrial oxygen consumption rate
Timeframe: At baseline and at 6 months
Change in spare respiratory capacity
Timeframe: At baseline and at 6 months
Change in mitochondrial maximal respiration
Timeframe: At baseline and at 6 months
Change in mitochondrial basal respiration
Timeframe: At baseline and at 6 months
Change in non-mitochondrial respiration
Timeframe: At baseline and at 6 months
Change in body fat percentage
Timeframe: At baseline and at 6 months
Change in diastolic arterial pressure
Timeframe: At baseline and at 6 months