CompletedNot Applicable

OCT Angiography Drived Alterations in Thyroid-associated Orbitopathy

Croatia68 participantsStarted 2024-12-09

Plain-language summary

The aim of this observational study is to evaluate retinal microvascular alterations in patients with thyroid-associated orbitopathy (TAO) using optical coherence tomography angiography (OCTA). The specific objectives are: * To assess the impact of extraocular muscle (EOM) enlargement on vessel density in the superficial and deep retinal capillary plexuses in patients with TAO. * To determine the effect of increased orbital fat volume on superficial and deep retinal vessel density in TAO. * To evaluate the relationship between disease activity, as measured by the Clinical Activity Score (CAS), and retinal microvascular density in patients with TAO.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * adult patients (≥18 years) of both sexes with a confirmed diagnosis of TAO treated at University Hospital Osijek. Exclusion Criteria: * anterior segment pathology (e.g., central keratopathy), * primary open- or closed-angle glaucoma, * posterior segment disorders (e.g., diabetic retinopathy, age-related macular degeneration, retinal vascular occlusion), * previous ocular trauma or uveitis, * refractive errors exceeding ±6.0 Diopter sphere or ±3.0 Diopter cylinder * media opacities that compromised angio optical OCTA image quality, * contraindication for orbital MRI

What they're measuring

Retinal vessel density (VD)

Timeframe: Baseline

Trial details

NCT IDNCT07341347

SponsorOsijek University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-15

View on ClinicalTrials.gov More Thyroid Associated Orbitopathy trials