CompletedNot Applicable

OCT Angiography Drived Alterations in Thyroid-associated Orbitopathy

Croatia68 participantsStarted 2024-12-09

Plain-language summary

The aim of this observational study is to evaluate retinal microvascular alterations in patients with thyroid-associated orbitopathy (TAO) using optical coherence tomography angiography (OCTA). The specific objectives are: * To assess the impact of extraocular muscle (EOM) enlargement on vessel density in the superficial and deep retinal capillary plexuses in patients with TAO. * To determine the effect of increased orbital fat volume on superficial and deep retinal vessel density in TAO. * To evaluate the relationship between disease activity, as measured by the Clinical Activity Score (CAS), and retinal microvascular density in patients with TAO.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adult patients (≥18 years) of both sexes with a confirmed diagnosis of TAO treated at University Hospital Osijek. Exclusion Criteria: * anterior segment pathology (e.g., central keratopathy), * primary open- or closed-angle glaucoma, * posterior segment disorders (e.g., diabetic retinopathy, age-related macular degeneration, retinal vascular occlusion), * previous ocular trauma or uveitis, * refractive errors exceeding ±6.0 Diopter sphere or ±3.0 Diopter cylinder * media opacities that compromised angio optical OCTA image quality, * contraindication for orbital MRI

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Retinal vessel density (VD)

Timeframe: Baseline

Trial details

NCT IDNCT07341347

SponsorOsijek University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-15

View on ClinicalTrials.gov More Thyroid Associated Orbitopathy trials