CompletedNot Applicable

Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning

Egypt36 participantsStarted 2024-11-11

Plain-language summary

The aim of this study is to evaluate how smoking affects the healing process of the gums after treatment. The researchers will measure the levels of two specific proteins (PLAP-1 and Sclerostin) in the gum fluid of patients with stage II periodontitis. These measurements will be compared between smokers and non-smokers before and after receiving non-surgical periodontal therapy (cleaning and scaling) to see if smoking changes the body's response to treatment.

Who can participate

Age range

25 Years – 40 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female aged from 25 - 40 years old. * Patients diagnosed as having Stage II periodontitis. * Group of current smoker's patients, more than 10 cigarettes per day. * Group of non-smoker's patients. * Maximum probing depth ≤ 5 mm, mostly horizontal bone loss. * Clinical Attachment loss from 3-4 mm. * Radiographic bone loss about 15% to 33%, mostly horizontal. Exclusion Criteria: * Pregnant or lactating women. * Any known systemic disease. * Patients who received periodontal treatment in last 6 months.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

change in periodontal ligament associated protien-1 levels

Timeframe: Baseline (before treatment) and 6 months after treatment

Change in Sclerostin levels

Timeframe: Baseline and 6 months after treatment

Trial details

NCT IDNCT07339670

SponsorAl-Azhar University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-04-11

View on ClinicalTrials.gov More Smoking ( Cigarette) trials