CompletedNot Applicable

Study of Gum Tissue Proteins in Smokers vs. Non-smokers After Cleaning

Egypt36 participantsStarted 2024-11-11

Plain-language summary

The aim of this study is to evaluate how smoking affects the healing process of the gums after treatment. The researchers will measure the levels of two specific proteins (PLAP-1 and Sclerostin) in the gum fluid of patients with stage II periodontitis. These measurements will be compared between smokers and non-smokers before and after receiving non-surgical periodontal therapy (cleaning and scaling) to see if smoking changes the body's response to treatment.

Who can participate

Age range25 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male or female aged from 25 - 40 years old. * Patients diagnosed as having Stage II periodontitis. * Group of current smoker's patients, more than 10 cigarettes per day. * Group of non-smoker's patients. * Maximum probing depth ≤ 5 mm, mostly horizontal bone loss. * Clinical Attachment loss from 3-4 mm. * Radiographic bone loss about 15% to 33%, mostly horizontal. Exclusion Criteria: * Pregnant or lactating women. * Any known systemic disease. * Patients who received periodontal treatment in last 6 months.

What they're measuring

change in periodontal ligament associated protien-1 levels

Timeframe: Baseline (before treatment) and 6 months after treatment

Change in Sclerostin levels

Timeframe: Baseline and 6 months after treatment

Trial details

NCT IDNCT07339670

SponsorAl-Azhar University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-04-11

View on ClinicalTrials.gov More Smoking ( Cigarette) trials