Whole-Body Vibration Versus Neuro Muscular Electrical Stimulation on Patients With ICU Acquired W… (NCT07336810) | Clinical Trial Compass
CompletedNot Applicable
Whole-Body Vibration Versus Neuro Muscular Electrical Stimulation on Patients With ICU Acquired Weakness
Egypt60 participantsStarted 2026-01-10
Plain-language summary
Purpose: to investigate the effect of Whole-body vibration versus neuro-muscular electrical stimulation on patients with intensive care-acquired weakness. Methods: Sixty patients with Intensive Care Unit-acquired weakness (ICU AW) from both genders will be recruited and randomly assigned into two groups, Group A and Group B. Group A will include 30 patients who will practice Whole body vibration for two weeks twice daily in addition to their plan of treatment. Group B will include 30 patients who will receive neuromuscular electrical stimulation for two weeks, twice daily, in addition to their plan of treatment. All patients will be evaluated pre- and post-treatment for the MRC score, creatine phosphokinase, and total muscle strength and skeletal muscle thickness
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ICU patients who were aged ≥ 18 and \<65.
* Sepsis-related Organ Failure assessments (SOFA) score ≥ 9 within the first 72 h after ICU admission.
* Patients with no central and peripheral nervous system injury.
* Expected to be treated in the ICU for more than 1 week.
* Medical Research Council (MRC) sum score of less than 36/60.
* Dominant-hand handgrip dynamometry scores of less than 11 kg (interquartile range (IQR) 10-40) in males and less than 7 kg (IQR 0-7.3) in females
Exclusion Criteria:
* Patients with comorbidities interfering with or compromising the training, like cardiac arrhythmia, pericardial effusion, congestive heart failure, or unstable acute coronary syndrome.
* Patients are hemodynamically unstable.
* Patients who had a major neurological deficit (upper motor neuron lesion).
* Age \< 18 years and more than 65.
* Implanted pacemaker or defibrillator.
* Pregnancy.
* Unhealed fractures or recently attached implants in the body region to be stimulated.
* Acute venous thrombosis.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial compared whole-body vibration to neuromuscular electrical stimulation for ICU-acquired weakness — given my specific situation in the ICU, which of these two approaches, if either, does my care team think would be more appropriate for me to discuss?
2The trial measured muscle strength using the MRC scale and muscle thickness — can you explain what my current scores on those measures look like, and whether they suggest I'm experiencing the kind of weakness this study was targeting?
3Since this trial is already completed, have the results been published or shared anywhere, and what did they find about whether whole-body vibration or electrical stimulation worked better for rebuilding muscle in ICU patients?
4The study also tracked creatine phosphokinase (CPK-MM) levels as a marker of muscle damage — is monitoring that enzyme something that makes sense for my care right now, and what would the results tell us?
5Are there standard rehabilitation approaches already used in this ICU for patients with muscle weakness, and how do they compare to the two interventions tested in this trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Manual muscle test (MMT)
Timeframe: At baseline and post two weeks
2
Medical Research Council (MRC)
Timeframe: At baseline and post two weeks
3
change of Creatine phosphokinase (CPK-MM)
Timeframe: change from baseline CPK-MM level at 2 weeks