RecruitingNot Applicable

Effect of Vitamin A Supplementation on Idiopathic Scoliosis

China140 participantsStarted 2025-05-13

Plain-language summary

This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.

Who can participate

Age range6 Years – 15 Years

SexALL

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Inclusion criteria

✓. Age between 6 and 15 years.
✓. Biochemically confirmed vitamin A deficiency (serum retinol \< 0.20 mg/L) or insufficiency (serum retinol 0.20-0.29 mg/L).
✓. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.
✓. Skeletally immature (Risser sign 0-3) with a major Cobb angle \< 40 degrees at baseline.
✓. Written informed consent/assent provided by the participant and legal guardian.

Exclusion criteria

✕. Unwillingness or inability to comply with all study procedures and follow-up visits.
✕. Plans to relocate outside the study area within the next 24 months.
✕. Previous high-dose vitamin A supplementation therapy within the past 12 months.
✕. Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots).
✕. Serum vitamin A level \> 0.70 mg/L (to avoid risk of hypervitaminosis A).
✕. Severe chronic health conditions that could confound study outcomes, including but not limited to:

What they're measuring

Scoliosis Curve Angle

Timeframe: Routine follow-up visits will be scheduled 6 months apart up to 24 months

Angle of Trunk Rotation

Timeframe: Routine follow-up visits will be scheduled 6 months apart up to 24 months

Trial details

NCT IDNCT07335991

SponsorSecond Affiliated Hospital of Wenzhou Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06-01

Contact for this trial

Xiangyang Wang, MD

86-13506663458 Xiangyangwang@wmu.edu.com

View on ClinicalTrials.gov More Vitamin A Deficiency trials